ARG41514
anti-Myosin Light Chain 2 antibody
anti-Myosin Light Chain 2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Myosin Light Chain 2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Myosin Light Chain 2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Myosin Light Chain 2. |
| 偶联标记 | Un-conjugated |
| 別名 | MLC2; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; CMH10; MLC-2; MLC-2v |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse heart | ||||||||
| 实际分子量 | 19 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYL2 |
| 全名 | myosin, light chain 2, regulatory, cardiac, slow |
| 背景介绍 | Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
| 细胞定位 | Cytoplasm, myofibril, sarcomere, A band. [UniProt] |
| 预测分子量 | 19 kDa |
| 翻译后修饰 | N-terminus is methylated by METTL11A/NTM1. Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity). [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG41514 anti-Myosin Light Chain 2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human heart tissue stained with ARG41514 anti-Myosin Light Chain 2 antibody.
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ARG41514 anti-Myosin Light Chain 2 antibody WB image
Western blot: Mouse heart lysate stained with ARG41514 anti-Myosin Light Chain 2 antibody.
