ARG44223
anti-MyT1L antibody
anti-MyT1L antibody for Flow cytometry,ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MyT1L |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MyT1L |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human MyT1L |
| 偶联标记 | Un-conjugated |
| Protein Full name | Myelin transcription factor 1-like protein |
| 別名 | MYT1L; Myelin Transcription Factor 1 Like; KIAA1106; ZC2HC4B; ZC2H2C2; NZF1; Myelin Transcription Factor 1-Like Protein; Neural Zinc Finger Transcription Factor 1; MyT1-L; MRD39; MyT1L |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UL68 Human Myelin transcription factor 1-like protein |
|---|---|
| 基因名称 | MYT1L |
| 全名 | Myelin Transcription Factor 1 Like |
| 背景介绍 | This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. |
| 细胞定位 | Chromosome, Nucleus |
| 产品亮点 | Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. |
| 预测分子量 | 133 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG44223 anti-MyT1L antibody ICC/IF image
Immunofluorescence: U2OS stained with ARG44223 anti-MyT1L antibody at 5 μg/mL dilution.
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ARG44223 anti-MyT1L antibody WB image
Western blot: HepG2 and HeLa stained with ARG44223 anti-MyT1L antibody at 0.5 μg/mL dilution.
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ARG44223 anti-MyT1L antibody FACS image
Flow Cytometry: HepG2 stained with ARG44223 anti-MyT1L antibody at 1 μg/1x10^6 cells dilution.
