ARG52343
anti-Munc18 phospho (Ser 515) antibody
anti-Munc18 phospho (Ser 515) antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Rat
Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Munc18 phospho (Ser 515) |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Hu, Ms, Bov, Chk, Dog, NHuPrm, Xenopus laevis |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Munc18 |
| 抗原物种 | Rat |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser515 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | Protein unc-18 homolog B; UNC18-2; Unc-18B; MUNC18-2; Unc18-2; Protein unc-18 homolog 2; UNC18B; FHL5; pp10122; Hunc18b; Syntaxin-binding protein 2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~65k Munc-18 protein phosphorylated at Ser513 . Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | STXBP2 |
| 全名 | syntaxin binding protein 2 |
| 背景介绍 | Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Unc-18 is thought to be regulated by PKC phosphorylation of Ser515 in C. Elegans (Sassa et al., 1996). Ser513 is the mammalian homologue of Ser515 in C. Elegans. |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 66 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52343 anti-Munc18 phospho (Ser 515) antibody WB image
Western blot: Rat cortex lysate showing phospho-specific immunolabeling of the ~65k Munc-18 stained with phosphorylated at Ser 515 stained with ARG52343 anti-Munc18 phospho (Ser 515) antibody.
