ARG45543
anti-Mucin 5AC antibody [45M1]
anti-Mucin 5AC antibody [45M1] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat,Rabbit
概述
| 产品描述 | Mouse Monoclonal antibody [45M1] recognizes MUC5B |
|---|---|
| 反应物种 | Hu, Rat, Rb |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 45M1 |
| 同位型 | IgG1 |
| 靶点名称 | Mucin 5AC |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | leB; Major airway glycoprotein; Lewis B blood group antigen; Tracheobronchial mucin; mucin; Mucin-5AC; LeB; MUC5; TBM; Gastric mucin; MUC-5AC; Mucin-5 subtype AC, tracheobronchial |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Ascites |
| 缓冲液 | Mouse ascites fluid, 1.2% Sodium acetate, 0.01 mg Sodium azide and 2 mg BSA. |
| 抗菌剂 | 0.01 mg Sodium azide |
| 稳定剂 | 2 mg BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MUC5AC |
| 全名 | mucin 5AC, oligomeric mucus/gel-forming |
| 背景介绍 | Predicted to enable extracellular matrix constituent, lubricant activity. Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within maintenance of lens transparency. Located in extracellular space and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple). [provided by Alliance of Genome Resources, Feb 2025] |
| 生物功能 | Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 586 kDa |
| 翻译后修饰 | C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45543 anti-Mucin 5AC antibody [45M1] IHC-P image
Immunohistochemistry: Human colon cancer stained with ARG45543 anti-Mucin 5AC antibody [45M1] at 2 μg/ml dilution.
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ARG45543 anti-Mucin 5AC antibody [45M1] IHC-P image
Immunohistochemistry: Rat colon stained with ARG45543 anti-Mucin 5AC antibody [45M1] at 2 μg/ml dilution.
