ARG42474
anti-Metallothionein antibody
anti-Metallothionein antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Metallothionein. |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 特异性 | This antibody might also react to Metallothionein-1 and Metallothionein-2 proteins based on the sequence homology analysis. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Metallothionein |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-61 of Human Metallothionein 2A. (NP_005944.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Metallothionein-2A; MT2; Metallothionein-II; MT-2; Metallothionein-2; MT-II; Metallothionein 1; MT-1; Metallothionein family proteins |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa | ||||||
| 实际分子量 | 15 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MT2; MT1 |
| 全名 | metallothionein |
| 背景介绍 | This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017] |
| 生物功能 | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. [UniProt] |
| 预测分子量 | 6 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG42474 anti-Metallothionein antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat pancreas tissue stained with ARG42474 anti-Metallothionein antibody at 1:200 dilution.
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ARG42474 anti-Metallothionein antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG42474 anti-Metallothionein antibody at 1:1000 dilution.
