ARG59138
anti-Mast Cell Tryptase antibody
anti-Mast Cell Tryptase antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Mast Cell Tryptase |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Mast Cell Tryptase |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Mast Cell Tryptase. |
| 偶联标记 | Un-conjugated |
| 別名 | TPSB1; Tryptase I; Tryptase alpha-1; Tryptase alpha/beta-1; TPS1; TPS2; EC 3.4.21.59; Tryptase-1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 30 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TPSAB1 |
| 全名 | tryptase alpha/beta 1 |
| 背景介绍 | Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] |
| 生物功能 | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates. [UniProt] |
| 细胞定位 | Secreted. Note=Released from the secretory granules upon mast cell activation. [UniProt] |
| 预测分子量 | 31 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG59138 anti-Mast Cell Tryptase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney stained with ARG59138 anti-Mast Cell Tryptase antibody.
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ARG59138 anti-Mast Cell Tryptase antibody WB image
Western blot: Human tonsil lysate stained with ARG59138 anti-Mast Cell Tryptase antibody.
