ARG42164
anti-MYL12B antibody
anti-MYL12B antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MYL12B |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MYL12B |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 1-30 of Human MYL12B. |
| 偶联标记 | Un-conjugated |
| 別名 | MLC-B; MLC20; SHUJUN-1; Myosin regulatory light chain MRLC2; Myosin regulatory light chain 12B; MLC-2; MRLC2; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain 2-B, smooth muscle isoform; MLC-2A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human placenta | ||||
| 实际分子量 | ~ 18 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYL12B |
| 全名 | myosin, light chain 12B, regulatory |
| 背景介绍 | This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Dec 2014] |
| 生物功能 | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. [UniProt] |
| 预测分子量 | 20 kDa |
| 翻译后修饰 | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42164 anti-MYL12B antibody WB image
Western blot: 35 µg of Human placenta lysate stained with ARG42164 anti-MYL12B antibody.
