ARG42200
anti-MYL12 antibody
anti-MYL12 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MYL12 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody might react to MYL12A, MYL12B and MYL9 proteins. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MYL12 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 92-171 of Human MYL12 (NP_006462.1). |
| 偶联标记 | Un-conjugated |
| 別名 | MLCB; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3; Myosin regulatory light chain 12A; HEL-S-24; MYL2B; MRLC3; MLC-2B; MRCL3; Epididymis secretory protein Li 24 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Jurkat | ||||
| 实际分子量 | ~ 17 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYL12A |
| 全名 | myosin, light chain 12A, regulatory, non-sarcomeric |
| 背景介绍 | This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Dec 2014] |
| 生物功能 | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). [UniProt] |
| 预测分子量 | 20 kDa |
| 翻译后修饰 | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42200 anti-MYL12 antibody WB image
Western blot: 25 µg of Jurkat cell lysate stained with ARG42200 anti-MYL12 antibody at 1:3000 dilution.
