anti-MYH11 / SMMHC antibody [SQab20185]

anti-MYH11 / SMMHC antibody [SQab20185] for IHC-Formalin-fixed paraffin-embedded sections and Human


产品描述 Recombinant Rabbit Monoclonal antibody [SQab20185] recognizes MYH11 / SMMHC
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab20185
同位型 IgG
靶点名称 MYH11 / SMMHC
抗原物种 Human
抗原 Synthetic peptide within aa. 1-100 of Human MYH11 / SMMHC.
偶联标记 Un-conjugated
別名 Myosin-11; Myosin heavy chain, smooth muscle isoform; AAT4; SMMHC; FAA4; SMHC; Myosin heavy chain 11


应用 推荐稀释比
IHC-P1:100 - 1:200
应用说明 IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Liomyoma tissue.


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05% BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 4629 Human MYH11

Swiss-port # P35749 Human Myosin-11

基因名称 MYH11
全名 myosin, heavy chain 11, smooth muscle
背景介绍 The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
生物功能 Muscle contraction. [UniProt]
细胞定位 Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils. [UniProt]
预测分子量 227 kDa

检测图片 (1) Click the Picture to Zoom In

  • ARG66752 anti-MYH11 / SMMHC antibody [SQab20185] IHC-P image

    Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human liomyoma tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66752 anti-MYH11 / SMMHC antibody [SQab20185] at 18°C - 25°C for 30 minutes.