ARG56064
anti-MYH11 / SMMHC antibody [SMMS-1]
anti-MYH11 / SMMHC antibody [SMMS-1] for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Rabbit
参考文献2
概述
| 产品描述 | Mouse Monoclonal antibody [SMMS-1] recognizes MYH11 / SMMHC |
|---|---|
| 反应物种 | Hu, Rb |
| 应用 | FACS, ICC/IF, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SMMS-1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | MYH11 / SMMHC |
| 抗原物种 | Human |
| 抗原 | Human uterus extract. |
| 偶联标记 | Un-conjugated |
| 別名 | Myosin-11; Myosin heavy chain, smooth muscle isoform; AAT4; SMMHC; FAA4; SMHC; Myosin heavy chain 11 |
应用说明
| 交叉反应性说明 | Reference: doi:10.1016/j.apmt.2021.101198 stained rabbit samples by ARG56064 anti-MYH11 / SMMHC antibody [SMMS-1]. | ||||||||
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| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
GeneID: 100009145 Rabbit MYH11 |
|---|---|
| 基因名称 | MYH11 |
| 全名 | myosin, heavy chain 11, smooth muscle |
| 背景介绍 | The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| 生物功能 | Muscle contraction. [UniProt] |
| 细胞定位 | Cytoplasmic |
| 预测分子量 | 227 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG56064 anti-MYH11 / SMMHC antibody [SMMS-1] IHC-P image
Immunohistochemistry: Rabbit carotid artery graft stained with ARG56064 anti-MYH11 / SMMHC antibody [SMMS-1].
From Yi B et al. Bioactive Materials. (2022), doi: 10.1016/j.bioactmat.2022.07.010, Fig. 1. 0. C.
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ARG56064 anti-MYH11 / SMMHC antibody [SMMS-1] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human Leiomyosarcoma stained with ARG56064 anti-MYH11 / SMMHC antibody [SMMS-1].
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