ARG40456
anti-MYH10 antibody
anti-MYH10 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MYH10 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MYH10 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1908-2007 of Human MYH10 (NP_001242941.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Myosin-10; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHCB; Non-muscle myosin heavy chain B; NMMHC II-b; NMMHC-IIB; Myosin heavy chain, non-muscle IIb; Cellular myosin heavy chain, type B; Myosin heavy chain 10 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HT-29 | ||||
| 实际分子量 | 250 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MYH10 |
| 全名 | myosin, heavy chain 10, non-muscle |
| 背景介绍 | This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| 生物功能 | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. [UniProt] |
| 细胞定位 | Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells. [UniProt] |
| 预测分子量 | 229 kDa |
| 翻译后修饰 | Phosphorylated by ABL2. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG40456 anti-MYH10 antibody WB image
Western blot: 25 µg of HT-29 cell lysate stained with ARG40456 anti-MYH10 antibody at 1:3000 dilution.
