ARG55679
anti-MYBPC3 antibody
anti-MYBPC3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MYBPC3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MYBPC3 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 189-218 (N-terminus) of Human MYBPC3. |
| 偶联标记 | Un-conjugated |
| 別名 | LVNC10; CMD1MM; MYBP-C; Cardiac MyBP-C; Myosin-binding protein C, cardiac-type; FHC; C-protein, cardiac muscle isoform; CMH4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human liver |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P56741 Rat Myosin-binding protein C, cardiac-type Swiss-port # Q14896 Human Myosin-binding protein C, cardiac-type |
|---|---|
| 基因名称 | MYBPC3 |
| 全名 | myosin binding protein C, cardiac |
| 背景介绍 | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
| 生物功能 | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. [UniProt] |
| 预测分子量 | 141 kDa |
| 翻译后修饰 | Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction (By similarity). Polyubiquitinated. |
检测图片 (2) Click the Picture to Zoom In
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ARG55679 anti-MYBPC3 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human heart tissue stained with ARG55679 anti-MYBPC3 antibody.
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ARG55679 anti-MYBPC3 antibody WB image
Western blot: 20 µg of Human liver lysate stained with ARG55679 anti-MYBPC3 antibody at 1:1000 - 1:2000 dilution.
