ARG59023
anti-MXD1 / Mad antibody
anti-MXD1 / Mad antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MXD1 / Mad |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MXD1 / Mad |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to M1-L221 of Human Mad. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein MAD; BHLHC58; MAD1; Max dimerization protein 1; MAD; Max dimerizer 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | MXD1 |
|---|---|
| 全名 | MAX dimerization protein 1 |
| 背景介绍 | This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] |
| 生物功能 | Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 25 kDa |
| 翻译后修饰 | Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG59023 anti-MXD1 / Mad antibody WB image
Western blot: 50 µg of samples under reducing conditions. Rat testis and Mouse ovary lysates stained with ARG59023 anti-MXD1 / Mad antibody at 0.5 µg/ml, overnight at 4°C.
