ARG67266
anti-MVP / LRP antibody [SQab30382]
anti-MVP / LRP antibody [SQab30382] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Monoclonal antibody [SQab30382] recognizes MVP / LRP. |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30382 |
| 同位型 | IgG |
| 靶点名称 | MVP / LRP |
| 抗原 | Synthetic peptide. |
| 偶联标记 | Un-conjugated |
| 別名 | MVP; Major Vault Protein; LRP; Lung Resistance-Related Protein; VAULT1; Testicular Secretory Protein Li 30 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MVP |
| 全名 | Major Vault Protein |
| 背景介绍 | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| 生物功能 | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [Uniprot] |
| 细胞定位 | Cytoplasm, Nuclear pore complex, Nucleus. [Uniprot] |
| 预测分子量 | 99 kDa |
| 翻译后修饰 | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
-
ARG67266 anti-MVP / LRP antibody [SQab30382] IHC-P image
Immunohistochemistry: Human Endometrial Cancer stained with ARG67266 anti-MVP / LRP antibody [SQab30382] at 1:100 dilution.
