ARG56103
anti-MVP / LRP antibody [1014]
anti-MVP / LRP antibody [1014] for ICC/IF,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [ 1014 ] recognizes MVP / LRP |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1014 |
| 同位型 | IgG1, kappa |
| 靶点名称 | MVP / LRP |
| 抗原物种 | Human |
| 抗原 | Proteins precipitated from Human breast cancer MCF-7 cells. |
| 偶联标记 | Un-conjugated |
| 別名 | MVP; LRP; VAULT1; Lung resistance-related protein; Major vault protein |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MVP |
| 全名 | major vault protein |
| 背景介绍 | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| 生物功能 | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [UniProt] |
| 细胞定位 | Cytoplasmic |
| 预测分子量 | 99 kDa |
| 翻译后修饰 | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
