ARG44427
anti-MUTYH antibody
anti-MUTYH antibody for Flow cytometry,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MUTYH |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MUTYH |
| 抗原物种 | Human |
| 抗原 | Human MUTYH recombinant protein (aa. sequence: M1-R559). |
| 偶联标记 | Un-conjugated |
| 別名 | MUTYH; MutY DNA Glycosylase; MYH; Adenine DNA Glycosylase; MutY Homolog; A/G-Specific Adenine DNA Glycosylase; MutY Homolog (E. Coli); MutY-Like Protein |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8R5G2 Rat A/G-specific adenine DNA glycosylase Swiss-port # Q9UIF7 Human A/G-specific adenine DNA glycosylase |
|---|---|
| 基因名称 | MUTYH |
| 全名 | MutY DNA Glycosylase |
| 背景介绍 | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. |
| 细胞定位 | Mitochondrion, Nucleus |
| 预测分子量 | 60 kDa |
检测图片 (3) Click the Picture to Zoom In
-
ARG44427 anti-MUTYH antibody WB image
Western blot: HeLa and K562 stained with ARG44427 anti-MUTYH antibody at 0.5 μg/mL dilution.
-
ARG44427 anti-MUTYH antibody FACS image
Flow Cytometry: HeLa stained with ARG44427 anti-MUTYH antibody at 1 μg/10^6 cells dilution.
-
ARG44427 anti-MUTYH antibody WB image
Western blot: C6 stained with ARG44427 anti-MUTYH antibody at 0.5 μg/mL dilution.
