ARG43650
anti-MUS81 antibody
anti-MUS81 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MUS81 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MUS81 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein fragment corresponding to N-terminal region of Human MUS81. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Crossover junction endonuclease |
| 別名 | Crossover junction endonuclease MUS81; SLX3; EC 3.1.22.- |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~70 - 72 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MUS81 |
| 全名 | MUS81 structure-specific endonuclease subunit |
| 背景介绍 | This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017] |
| 生物功能 | Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. [UniProt] |
| 细胞定位 | Nucleus, nucleolus |
| 预测分子量 | 61 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG43650 anti-MUS81 antibody WB image
Western blot: HeLa and Jurkat stained with ARG43650 anti-MUS81 antibody at 1:1000 dilution.
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ARG43650 anti-MUS81 antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG43650 anti-MUS81 antibody at 1:100 dilution.
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ARG43650 anti-MUS81 antibody IHC-P image
Immunohistochemistry: Mouse brain stained with ARG43650 anti-MUS81 antibody at 1:100 dilution.
