ARG59800

anti-MTGR1 antibody

anti-MTGR1 antibody for ICC/IF,Western blot and Human,Mouse,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes MTGR1
反应物种 Hu, Ms, Rat
应用 ICC/IF, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 MTGR1
抗原物种 Human
抗原 Recombinant fusion protein corresponding to aa. 325-604 of Human MTGR1 (NP_005084.1).
偶联标记 Un-conjugated
別名 EHT; MTG8-related protein 1; ETO homologous on chromosome 20; MTGR1; p85; ZMYND3; Protein CBFA2T2; MTG8-like protein; Myeloid translocation-related protein 1

应用说明

应用建议
应用 推荐稀释比
ICC/IF1:50 - 1:100
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Rat brain, Mouse brain and Raji
实际分子量 72 kDa

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 12396 Mouse CBFA2T2

GeneID: 9139 Human CBFA2T2

Swiss-port # O43439 Human Protein CBFA2T2

Swiss-port # O70374 Mouse Protein CBFA2T2

基因名称 CBFA2T2
全名 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
背景介绍 In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
生物功能 May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. [UniProt]
细胞定位 Nucleus. [UniProt]
预测分子量 67 kDa

检测图片 (2) Click the Picture to Zoom In

  • ARG59800 anti-MTGR1 antibody ICC/IF image

    Immunofluorescence: U2OS cells stained with ARG59800 anti-MTGR1 antibody.

  • ARG59800 anti-MTGR1 antibody WB image

    Western blot: 25 µg of Rat brain, Mouse brain and Raji cell lysates stained with ARG59800 anti-MTGR1 antibody at 1:1000 dilution.