ARG43105
anti-MTDH / AEG1 antibody
anti-MTDH / AEG1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes MTDH / AEG1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | MTDH / AEG1 |
| 抗原物种 | Human |
| 抗原 | Purified recombinant fragment of Human MTDH / AEG1. |
| 偶联标记 | Un-conjugated |
| 別名 | 3D3/LYRIC; AEG-1; Metastasis adhesion protein; 3D3; LYRIC/3D3; AEG1; Protein LYRIC; Lysine-rich CEACAM1 co-isolated protein; LYRIC; Metadherin; Astrocyte elevated gene-1 protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | MCF7 | ||||||||
| 实际分子量 | ~ 73 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Unpurified |
| 缓冲液 | Ascitic fluid and 0.03% Sodium azide. |
| 抗菌剂 | 0.03% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MTDH |
| 全名 | metadherin |
| 生物功能 | Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. [UniProt] |
| 预测分子量 | 64 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG43105 anti-MTDH / AEG1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver tissue stained with ARG43105 anti-MTDH / AEG1 antibody.
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ARG43105 anti-MTDH / AEG1 antibody WB image
Western blot: MCF7 cell lysate stained with ARG43105 anti-MTDH / AEG1 antibody at 1:5000 dilution.
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ARG43105 anti-MTDH / AEG1 antibody FACS image
Flow Cytometry: HeLa cells stained with ARG43105 anti-MTDH / AEG1 antibody (right histogram) and negative control (left histogram).
