ARG40434
anti-MTAP antibody
anti-MTAP antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MTAP |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MTAP |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-283 of Human MTAP (NP_002442.2). |
| 偶联标记 | Un-conjugated |
| 別名 | 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MSAP; LGMBF; EC 2.4.2.28; HEL-249; DMSFH; BDMF; S-methyl-5'-thioadenosine phosphorylase; MTAPase; MTAP; DMSMFH; c86fus |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | 293T | ||||||||
| 实际分子量 | 31 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q13126 Human S-methyl-5'-thioadenosine phosphorylase Swiss-port # Q9CQ65 Mouse S-methyl-5'-thioadenosine phosphorylase |
|---|---|
| 基因名称 | MTAP |
| 全名 | methylthioadenosine phosphorylase |
| 背景介绍 | This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 31 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG40434 anti-MTAP antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG40434 anti-MTAP antibody.
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ARG40434 anti-MTAP antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse liver stained with ARG40434 anti-MTAP antibody at 1:100 dilution.
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ARG40434 anti-MTAP antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG40434 anti-MTAP antibody at 1:1000 dilution.
