ARG40434

anti-MTAP antibody

anti-MTAP antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes MTAP
反应物种 Hu, Ms, Rat
应用 ICC/IF, IHC-P, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 MTAP
抗原物种 Human
抗原 Recombinant fusion protein corresponding to aa. 1-283 of Human MTAP (NP_002442.2).
偶联标记 Un-conjugated
別名 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MSAP; LGMBF; EC 2.4.2.28; HEL-249; DMSFH; BDMF; S-methyl-5'-thioadenosine phosphorylase; MTAPase; MTAP; DMSMFH; c86fus

应用说明

应用建议
应用 推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 293T
实际分子量 31 kDa

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 4507 Human MTAP

GeneID: 66902 Mouse MTAP

Swiss-port # Q13126 Human S-methyl-5'-thioadenosine phosphorylase

Swiss-port # Q9CQ65 Mouse S-methyl-5'-thioadenosine phosphorylase

基因名称 MTAP
全名 methylthioadenosine phosphorylase
背景介绍 This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
生物功能 Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. [UniProt]
细胞定位 Cytoplasm. Nucleus. [UniProt]
预测分子量 31 kDa

检测图片 (3) Click the Picture to Zoom In

  • ARG40434 anti-MTAP antibody ICC/IF image

    Immunofluorescence: A549 cells stained with ARG40434 anti-MTAP antibody.

  • ARG40434 anti-MTAP antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse liver stained with ARG40434 anti-MTAP antibody at 1:100 dilution.

  • ARG40434 anti-MTAP antibody WB image

    Western blot: 25 µg of 293T cell lysate stained with ARG40434 anti-MTAP antibody at 1:1000 dilution.