ARG43071
anti-MTA2 antibody
anti-MTA2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MTA2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MTA2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human MTA2. |
| 偶联标记 | Un-conjugated |
| 別名 | p53 target protein in deacetylase complex; MTA1L1; PID; Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein |
应用说明
| 应用建议 |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | HeLa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O94776 Human Metastasis-associated protein MTA2 |
|---|---|
| 基因名称 | MTA2 |
| 全名 | metastasis associated 1 family, member 2 |
| 背景介绍 | This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011] |
| 生物功能 | May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 75 kDa |
检测图片 (2) Click the Picture to Zoom In
-
ARG43071 anti-MTA2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon tissue stained with ARG43071 anti-MTA2 antibody at 1:100 dilution.
-
ARG43071 anti-MTA2 antibody WB image
Western blot: HeLa cell lysate stained with ARG43071 anti-MTA2 antibody.
