概述

产品描述	Rabbit Polyclonal antibody recognizes MRP5
反应物种	Hu, Ms, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	MRP5
抗原物种	Human
抗原	Synthetic peptide of Human ABCC5
偶联标记	Un-conjugated
別名	ATP-binding cassette sub-family C member 5; EST277145; ABC33; pABC11; MOAT-C; Multidrug resistance-associated protein 5; MOATC; MRP5; Multi-specific organic anion transporter C; SMRP

应用说明

预测反应性说明	Mouse, Rat
应用建议	应用 推荐稀释比 WB 1:1000 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Jurkat

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 10057 Human ABCC5 GeneID: 116721 Rat ABCC5 GeneID: 27416 Mouse ABCC5 Swiss-port # O15440 Human Multidrug resistance-associated protein 5 Swiss-port # Q9QYM0 Rat Multidrug resistance-associated protein 5 Swiss-port # Q9R1X5 Mouse Multidrug resistance-associated protein 5 More
基因名称	ABCC5
全名	ATP-binding cassette, sub-family C (CFTR/MRP), member 5
背景介绍	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]
生物功能	Acts as a multispecific organic anion pump which can transport nucleotide analogs. [UniProt]
研究领域	Metabolism antibody; Signaling Transduction antibody
预测分子量	161 kDa

检测图片 (1) Click the Picture to Zoom In