概述

产品描述	Rabbit Polyclonal antibody recognizes MRP2
反应物种	Hu
应用	FACS, ICC/IF, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	MRP2
抗原物种	Human
抗原	Synthetic peptide derived from Human MRP2.
偶联标记	Un-conjugated
別名	DJS; ATP-binding cassette sub-family C member 2; CMOAT; ABC30; cMRP; Canalicular multidrug resistance protein; MRP2; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2

应用说明

应用建议	应用 推荐稀释比 FACS 1:100 ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	HepG2

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1244 Human ABCC2 Swiss-port # Q92887 Human Canalicular multispecific organic anion transporter 1
基因名称	ABCC2
全名	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
背景介绍	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
生物功能	Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. [UniProt]
细胞定位	Apical cell membrane > Multi-pass membrane protein. [UniProt]
预测分子量	174 kDa

检测图片 (1) Click the Picture to Zoom In