ARG44279
anti-MNK2B antibody
anti-MNK2B antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MNK2B |
|---|---|
| 反应物种 | Hu |
| 预测物种 | NHuPrm |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MNK2B |
| 抗原物种 | Human |
| 抗原 | MNK2A synthetic peptide |
| 偶联标记 | Un-conjugated |
| 別名 | MKNK2; MAPK Interacting Serine/Threonine Kinase 2; MNK2; GPRK7; MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2; MAP Kinase Interacting Serine/Threonine Kinase 2; MAP Kinase Signal-Integrating Kinase 2; G Protein-Coupled Receptor Kinase 7; MAPK Signal-Integrating Kinase 2; EC 2.7.11.1; Putative Map Kinase Interacting Kinase; EC 2.7.11,; Mnk2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA. |
| 稳定剂 | 50% Glycerol and 100 µg/ml BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 |
Swiss-port # Q9HBH9 Human MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|---|
| 基因名称 | MKNK2 |
| 全名 | MAPK Interacting Serine/Threonine Kinase 2 |
| 背景介绍 | This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. |
| 生物功能 | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
| 细胞定位 | Cytoplasm, Nucleus |
| 预测分子量 | 47 kDa |
| 翻译后修饰 | Phosphoprotein |
