anti-MMP3 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Rabbit Polyclonal antibody recognizes MMP3
|应用||ICC/IF, IHC-P, WB|
|抗原||KLH-conjugated synthetic peptide corresponding to aa. 30-59 (N-terminus) of Human MMP3.|
|別名||Transin-1; CHDS6; EC 220.127.116.11; SL-1; STMY1; Matrix metalloproteinase-3; STR1; STMY; MMP-3; Stromelysin-1|
|应用说明||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|纯化||Purification with Protein A and immunogen peptide.|
|缓冲液||PBS and 0.09% (W/V) Sodium azide|
|抗菌剂||0.09% (W/V) Sodium azide|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|全名||matrix metallopeptidase 3|
|背景介绍||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]|
|生物功能||Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. [UniProt]|
|细胞定位||Secreted, extracellular space, extracellular matrix|
|研究领域||Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody|
检测图片 (3) Click the Picture to Zoom In
ARG55262 anti-MMP3 antibody WB image
Western blot: 30 µg of MCF7, U2OS, U87-MG, 293T, MEF and NIH3T3 cell lysates stained with ARG55262 anti-MMP3 antibody at 1:500 dilution.
ARG55262 anti-MMP3 antibody ICC/IF image
Immunofluorescence: NCI-H460 cells stained with ARG55262 anti-MMP3 antibody (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI (blue) for nuclear staining.
ARG55262 anti-MMP3 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human tonsil tissue stained with ARG55262 anti-MMP3 antibody.