ARG43682
anti-MLLT10 / AF10 antibody
anti-MLLT10 / AF10 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MLLT10 / AF10 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody is expected to recognize both reported isoforms (NP_004632.1; NP_001009569.1). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MLLT10 / AF10 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human MLLT10 / AF10. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Protein AF-10 |
| 別名 | Protein AF-10; AF10; ALL1-fused gene from chromosome 10 protein; MLLT10 histone lysine methyltransferase DOT1L cofactor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 130 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MLLT10 |
| 全名 | MLLT10 histone lysine methyltransferase DOT1L cofactor |
| 背景介绍 | This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
| 生物功能 | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). [UniProt] |
| 细胞定位 | Nucleus |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 113 kDa |
| 翻译后修饰 | Isopeptide bond; Phosphoprotein; Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG43682 anti-MLLT10 / AF10 antibody WB image
Western blot: Hela stained with ARG43682 anti-MLLT10 / AF10 antibody.
