ARG58956
anti-MIP / Aquaporin 0 antibody
anti-MIP / Aquaporin 0 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MIP / Aquaporin 0 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MIP / Aquaporin 0 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 50-150 of Human MIP / Aquaporin 0 (NP_036196.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Aquaporin-0; LIM1; AQP0; Lens fiber major intrinsic protein; MIP26; CTRCT15; MP26 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 26 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P30301 Human Lens fiber major intrinsic protein Swiss-port # P51180 Mouse Lens fiber major intrinsic protein |
|---|---|
| 基因名称 | MIP |
| 全名 | major intrinsic protein of lens fiber |
| 背景介绍 | Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008] |
| 生物功能 | Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). [UniProt] |
| 细胞定位 | Cell junction, Cell membrane, Multi-pass membrane protein, gap junction. [UniProt] |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity). Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58956 anti-MIP / Aquaporin 0 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG58956 anti-MIP / Aquaporin 0 antibody at 1:100 dilution.
