ARG44144
anti-MGME1 antibody
anti-MGME1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Disease variant, Primary mitochondrial disease, Progressive external ophthalmoplegia
概述
| 产品描述 | Rabbit Polyclonal recognizes MGME1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MGME1 |
| 抗原物种 | Human |
| 抗原 | Human MGME1 recombinant protein (Position: K4-D310). |
| 偶联标记 | Un-conjugated |
| 別名 | MGME1; Mitochondrial Genome Maintenance Exonuclease 1; DDK1; BA504H3.4; C20orf72; Chromosome 20 Open Reading Frame 72; EC 3.1.-.-; MTDPS11 |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9BQP7 Human Mitochondrial genome maintenance exonuclease 1 |
|---|---|
| 基因名称 | MGME1 |
| 全名 | Mitochondrial Genome Maintenance Exonuclease 1 |
| 背景介绍 | The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. |
| 细胞定位 | Mitochondrion |
| 研究领域 | Disease variant, Primary mitochondrial disease, Progressive external ophthalmoplegia |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (4) Click the Picture to Zoom In
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ARG44144 anti-MGME1 antibody IHC-P image
Immunohistochemistry: Human colorectal adenocarcinoma stained with ARG44144 anti-MGME1 antibody at 2 μg/ml dilution.
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ARG44144 anti-MGME1 antibody ICC/IF image
Immunofluorescence: U2OS stained with ARG44144 anti-MGME1 antibody at 5 μg/ml dilution.
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ARG44144 anti-MGME1 antibody WB image
Western blot: A549 and HepG2 stained with ARG44144 anti-MGME1 antibody at 0.5 μg/ml dilution.
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ARG44144 anti-MGME1 antibody IHC-P image
Immunohistochemistry: Human thyroid cancer stained with ARG44144 anti-MGME1 antibody at 2 μg/ml dilution.
