ARG56051
anti-MFGE8 / Lactadherin antibody [SPM291]
anti-MFGE8 / Lactadherin antibody [SPM291] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [SPM291] recognizes MFGE8 / Lactadherin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SPM291 |
| 同位型 | IgG1, kappa |
| 靶点名称 | MFGE8 / Lactadherin |
| 抗原物种 | Human |
| 抗原 | A Human milk fat globule membrane preparation. |
| 偶联标记 | Un-conjugated |
| 別名 | SPAG10; MFGM; HsT19888; HMFG; Milk fat globule-EGF factor 8; MFG-E8; BA46; hP47; EDIL1; Lactadherin; OAcGD3S; Breast epithelial antigen BA46; SED1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MFGE8 |
| 全名 | milk fat globule-EGF factor 8 protein |
| 背景介绍 | This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| 生物功能 | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. Medin is the main constituent of aortic medial amyloid. [UniProt] |
| 细胞定位 | Cell surface and cytoplasmic |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. |
检测图片 (4) Click the Picture to Zoom In
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ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human breast carcinoma stained with ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291].
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ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human renal cell carcinoma stained with ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291].
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ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human pancreas stained with ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291].
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ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291] IHC-P image
Immunohistochemistry: Formalin-fixed, paraffin-embedded Human lung carcinoma stained with ARG56051 anti-MFGE8 / Lactadherin antibody [SPM291].
