ARG41986
anti-MEKK2 antibody
anti-MEKK2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MEKK2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MEKK2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human MEKK2. |
| 偶联标记 | Un-conjugated |
| 別名 | MAPK/ERK kinase kinase 2; MEKK2B; MEK kinase 2; EC 2.7.11.25; Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | HeLa | ||||||||||||
| 实际分子量 | ~ 73 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y2U5 Human Mitogen-activated protein kinase kinase kinase 2 |
|---|---|
| 基因名称 | MAP3K2 |
| 全名 | mitogen-activated protein kinase kinase kinase 2 |
| 背景介绍 | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. [UniProt] |
| 预测分子量 | 70 kDa |
| 翻译后修饰 | Autophosphorylated. Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG41986 anti-MEKK2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human thyroid cancer tissue stained with ARG41986 anti-MEKK2 antibody.
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ARG41986 anti-MEKK2 antibody WB image
Western blot: HeLa cell lysate stained with ARG41986 anti-MEKK2 antibody.
