ARG40732
anti-MDR1 / P Glycoprotein 1 antibody
anti-MDR1 / P Glycoprotein 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MDR1 / P Glycoprotein 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MDR1 / P Glycoprotein 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide from Human MDR1 / P Glycoprotein 1. |
| 偶联标记 | Un-conjugated |
| 別名 | PGY1; ABC20; P-GP; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; CD antigen CD243; GP170; CLCS; CD243; MDR1; EC 3.6.3.44; P-glycoprotein 1 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Suggest not boiling the sample after lysis and before loading into the gel. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ABCB1 |
| 全名 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| 背景介绍 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008] |
| 生物功能 | Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 141 kDa |
检测图片 (2) Click the Picture to Zoom In
-
ARG40732 anti-MDR1 / P Glycoprotein 1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG40732 anti-MDR1 / P Glycoprotein 1 antibody.
-
ARG40732 anti-MDR1 / P Glycoprotein 1 antibody WB image
Western blot: HeLa cell lysate stained with ARG40732 anti-MDR1 / P Glycoprotein 1 antibody.
文献引用
Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin
WB / Human
