ARG44703
anti-MDM4 / MDMX antibody
anti-MDM4 / MDMX antibody for Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes MDM4 / MDMX |
|---|---|
| 反应物种 | Hu |
| 应用 | IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | MDM4 / MDMX |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | Double minute 4 protein; p53-binding protein Mdm4; MDMX; Protein Mdm4; Mdm2-like p53-binding protein; HDMX; MRP1; Protein Mdmx |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MDM4 |
| 全名 | MDM4, p53 regulator |
| 背景介绍 | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] |
| 生物功能 | Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 55 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG44703 anti-MDM4 / MDMX antibody IP image
Immunoprecipitation: HeLa lysate immunoprecipitated with 2.5 µg of ARG44703 anti-MDM4 / MDMX antibody.
