ARG62541
anti-MCP5 / Mast cell chymase antibody [CC1]
anti-MCP5 / Mast cell chymase antibody [CC1] for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat,Pig
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [CC1] recognizes MCP5 / Mast cell chymase |
|---|---|
| 反应物种 | Hu, Rat, Pig |
| 应用 | FACS, IHC-Fr, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CC1 |
| 同位型 | IgG1 |
| 靶点名称 | MCP5 / Mast cell chymase |
| 抗原物种 | Human |
| 抗原 | Purified human skin Chymase |
| 偶联标记 | Un-conjugated |
| 別名 | Chymase; Alpha-chymase; Mast cell protease I; chymase; CYH; EC 3.4.21.39; MCT1 |
应用说明
| 应用说明 | FACS: 1-2µg for 106 cells IHC: 1/100-1/200 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunogen affinity purified |
| 缓冲液 | PBS, 1% BSA and 0.05% Sodium azide |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 1% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CMA1 |
| 全名 | chymase 1, mast cell |
| 背景介绍 | This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015] |
| 生物功能 | Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. [UniProt] |
| 细胞定位 | Secreted, Cytoplasmic granule |
| 研究领域 | Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 27 kDa |
克隆号文献
Stress management affects outcomes in the pathophysiology of an endometriosis model.
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
IHC-P / Human
Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog.
ICC/IF / Mouse
Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis.
IHC-P / Human
Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system.
WB / Pig
Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5.
WB / Rat
Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach.
IHC / Rat
