概述

产品描述	Rabbit Polyclonal recognizes MCF2
反应物种	Hu, Ms
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	MCF2
抗原	Recombinant fusion protein of human MCF2(aa sequence 872-1001)
偶联标记	Un-conjugated
別名	MCF2; MCF.2 Cell Line Derived Transforming Sequence; DBL; ARHGEF21; Oncogene MCF2 (Oncogene DBL); Proto-Oncogene MCF-2; Proto-Oncogene DBL

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:3000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
缓冲液	PBS (pH 7.3) and 0.01% Sodium azide.
抗菌剂	0.01% Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 4168 Human MCF2 Swiss-port # P10911 Human Proto-oncogene DBL
基因名称	MCF2
全名	MCF.2 Cell Line Derived Transforming Sequence
背景介绍	The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.
生物功能	Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
细胞定位	Cytoplasm, Membrane
预测分子量	108 kDa
翻译后修饰	Phosphoprotein

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