ARG45877
anti-MBD3 antibody
anti-MBD3 antibody for Western blot,ICC/IF and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MBD3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MBD3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to C-terminal region of human MBD3. |
| 偶联标记 | Un-conjugated |
| 別名 | Methyl-CpG Binding Domain Protein 3; MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 33 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95983 Human Methyl-CpG-binding domain protein 3 Swiss-port # Q9Z2D8 Mouse Methyl-CpG-binding domain protein 3 |
|---|---|
| 基因名称 | MBD3 |
| 全名 | Methyl-CpG Binding Domain Protein 3 |
| 背景介绍 | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| 生物功能 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. [UniProt] |
| 细胞定位 | Chromosome; Nucleus. [UniProt] |
| 预测分子量 | 32 kDa |
| 翻译后修饰 | Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45877 anti-MBD3 antibody ICC/IF image
Immunofluorescence: MBD3 stained with ARG45877 anti-MBD3 antibody at 5 μg/ml dilution.
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ARG45877 anti-MBD3 antibody WB image
Western blot: MCF-7 stained with ARG45877 anti-MBD3 antibody at 0.5 μg/ml dilution.
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ARG45877 anti-MBD3 antibody WB image
Western blot: Rat brain stained with ARG45877 anti-MBD3 antibody at 0.5 μg/ml dilution.
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ARG45877 anti-MBD3 antibody WB image
Western blot: Mouse brain stained with ARG45877 anti-MBD3 antibody at 0.5 μg/ml dilution.
