ARG42652
anti-MAdCAM1 antibody
anti-MAdCAM1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MAdCAM1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MAdCAM1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 173-190 of Human MAdCAM1. (EEPQGDEDVLFRVTERWR) |
| 偶联标记 | Un-conjugated |
| 別名 | Mucosal addressin cell adhesion molecule 1; hMAdCAM-1; MAdCAM-1; MACAM1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide, 0.05% Thimerosal and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide and 0.05% Thimerosal |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q13477 Human Mucosal addressin cell adhesion molecule 1 |
|---|---|
| 基因名称 | MADCAM1 |
| 全名 | mucosal vascular addressin cell adhesion molecule 1 |
| 背景介绍 | The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 40 kDa |
| 翻译后修饰 | The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42652 anti-MAdCAM1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human appendicitis tissue stained with ARG42652 anti-MAdCAM1 antibody.
