ARG44359
anti-MAN2B1 antibody
anti-MAN2B1 antibody for Western blot and Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MAN2B1 |
|---|---|
| 反应物种 | Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MAN2B1 |
| 抗原物种 | Human |
| 抗原 | Human MAN2B1 recombinant fusion protein (a.a. sequence: 640-850). |
| 偶联标记 | Un-conjugated |
| 別名 | MAN2B1; Mannosidase Alpha Class 2B Member 1; LAMAN; Lysosomal Alpha-Mannosidase; MANB; Lysosomal Acid Alpha-Mannosidase; Mannosidase Alpha-B; EC 3.2.1.24; Mannosidase, Alpha, Class 2B, Member 1; Mannosidase, Alpha B, Lysosomal; EC 3.2.1; Laman |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.02% sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
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| 基因名称 | MAN2B1 |
| 全名 | Mannosidase Alpha Class 2B Member 1 |
| 背景介绍 | This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages. |
| 细胞定位 | Lysosome |
| 预测分子量 | 114 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Zymogen |
检测图片 (1) Click the Picture to Zoom In
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ARG44359 anti-MAN2B1 antibody WB image
Western blot: Mouse liver stained with ARG44359 anti-MAN2B1 antibody at 1:1000 dilution.
