ARG58035
anti-MAGE1 antibody [MA454]
anti-MAGE1 antibody [MA454] for IHC-Formalin-fixed paraffin-embedded sections and Human,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [MA454] recognizes MAGE1 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | IHC-P |
| 特异性 | MAGE1 antibody clone MA454 recognizes a protein of 42-46kDa, identified as MAGE-1. This mAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, or -12 protein. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MA454 |
| 同位型 | IgG1, kappa |
| 靶点名称 | MAGE1 |
| 抗原物种 | Human |
| 抗原 | Full length Human MAGE1 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | CT1.1; MAGE-1 antigen; MAGE1; Antigen MZ2-E; Melanoma-associated antigen 1; Cancer/testis antigen 1.1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS, 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MAGEA1 |
| 全名 | melanoma antigen family A1 |
| 背景介绍 | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] |
| 生物功能 | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. [UniProt] |
| 预测分子量 | 34 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58035 anti-MAGE1 antibody [MA454] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human testis stained with ARG58035 anti-MAGE1 antibody [MA454].
