ARG43711
anti-Lrp2 / Megalin antibody
anti-Lrp2 / Megalin antibody for IHC-Formalin-fixed paraffin-embedded sections and Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Lrp2 / Megalin |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Lrp2 / Megalin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human Lrp2 / Megalin. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Low-density lipoprotein receptor-related protein 2 |
| 別名 | GP330; gp330; Glycoprotein 330; LRP-2; Megalin; Low-density lipoprotein receptor-related protein 2; DBS |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse Brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # A2ARV4 Mouse Low-density lipoprotein receptor-related protein 2 |
|---|---|
| 基因名称 | LRP2 |
| 全名 | low density lipoprotein receptor-related protein 2 |
| 背景介绍 | The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009] |
| 生物功能 | Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. [UniProt] |
| 细胞定位 | Apical cell membrane; Single-pass type I membrane protein. Endosome lumen. Membrane, coated pit. Cell projection, dendrite. Cell projection, axon. Note=Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form. [UniProt] |
| 预测分子量 | 522 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG43711 anti-Lrp2 / Megalin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG43711 anti-Lrp2 / Megalin antibody at 1:100 dilution.
