ARG44577
anti-LYRM4 antibody
anti-LYRM4 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LYRM4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LYRM4 |
| 抗原物种 | Human |
| 抗原 | Human LYRM4 recombinant protein (aa. sequence: M1-T91). |
| 偶联标记 | Un-conjugated |
| 別名 | LYRM4; LYR Motif Containing 4; ISD11; C6orf149; CGI-203; LYR Motif-Containing Protein 4; Mitochondrial Matrix Nfs1 Interacting Protein; Chromosome 6 Open Reading Frame 149; Homolog Of Yeast Isd11; COXPD19 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 15-17 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 抗菌剂 | 4% Trehalose |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LYRM4 |
| 全名 | LYR Motif Containing 4 |
| 背景介绍 | The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016] |
| 生物功能 | The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1. [Uniprot] |
| 细胞定位 | Mitochondrion, Nucleus. [Uniprot] |
| 预测分子量 | 11 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG44577 anti-LYRM4 antibody WB image
Western blot: Rat kidney stained with ARG44577 anti-LYRM4 antibody at 0.5 μg/mL dilution.
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ARG44577 anti-LYRM4 antibody WB image
Western blot: Mouse kidney stained with ARG44577 anti-LYRM4 antibody at 0.5 μg/mL dilution.
