ARG43764
anti-LRRK2 antibody
anti-LRRK2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LRRK2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LRRK2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to Human LRRK2. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Leucine-rich repeat serine/threonine-protein kinase 2 |
| 別名 | PARK8; RIPK7; ROCO2; AURA17; DARDARIN; Leucine-rich repeat serine/threonine-protein kinase 2; Parkinson Disease (Autosomal Dominant) 8; Augmented In Rheumatoid Arthritis 17 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.05% BSA, 40% Glycerol and 0.01% Sodium azide. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 0.05% BSA and 40% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q5S006 Mouse Leucine-rich repeat serine/threonine-protein kinase 2 Swiss-port # Q5S007 Human Leucine-rich repeat serine/threonine-protein kinase 2 |
|---|---|
| 基因名称 | LRRK2 |
| 全名 | leucine rich repeat kinase 2 |
| 背景介绍 | This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] |
| 生物功能 | LRRK2 (Leucine Rich Repeat Kinase 2) is a Protein Coding gene. Diseases associated with LRRK2 include Parkinson Disease 8, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by PTK6 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is BRAF. [GeneCard] |
| 细胞定位 | Cell projection; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome; Golgi apparatus; Lysosome; Membrane; Mitochondrion; Mitochondrion outer membrane; Synapse |
| 预测分子量 | 286 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG43764 anti-LRRK2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human thyroid stained with ARG43764 anti-LRRK2 antibody at 1:100 dilution. Antigen Retrieval: Heat mediated was performed using sodium citrate buffer (pH 6.0).
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ARG43764 anti-LRRK2 antibody WB image
Western blot: U87 MG cell lysate stained withARG43764 anti-LRRK2 antibody at 1:1000 dilution.
