ARG42366
anti-LRRC32 / GARP antibody [GARP5]
anti-LRRC32 / GARP antibody [GARP5] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [GARP5] recognizes LRRC32 / GARP |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | The mouse monoclonal antibody GARP5 recognizes GARP / LRRC32, an approximately 80 kDa glycoprotein expressed e.g. on the surface of megakaryocytes, platelets and activated Treg cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | GARP5 |
| 同位型 | IgG1 |
| 靶点名称 | LRRC32 / GARP |
| 抗原物种 | Human |
| 抗原 | Purified Human sGARP protein. |
| 偶联标记 | Un-conjugated |
| 別名 | D11S833E; Glycoprotein A repetitions predominant; Garpin; GARP; Leucine-rich repeat-containing protein 32 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q14392 Human Leucine-rich repeat-containing protein 32 |
|---|---|
| 基因名称 | LRRC32 |
| 全名 | leucine rich repeat containing 32 |
| 背景介绍 | This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008] |
| 生物功能 | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 72 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42366 anti-LRRC32 / GARP antibody [GARP5] WB image
Western blot: Human thrombocyte lysates stained with ARG42366 anti-LRRC32 / GARP antibody [GARP5], under reducing conditions.
