ARG58832
anti-LOXL1 antibody
anti-LOXL1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LOXL1 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Hm |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LOXL1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 397-425 of Human LOXL1 (AEEKCLASTAYAPEATDYDVRVLLRFPQR). |
| 偶联标记 | Un-conjugated |
| 別名 | Lysyl oxidase-like protein 1; Lysyl oxidase homolog 1; LOXL; LOL; EC 1.4.3.- |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LOXL1 |
| 全名 | lysyl oxidase-like 1 |
| 背景介绍 | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] |
| 生物功能 | Active on elastin and collagen substrates. [UniProt] |
| 细胞定位 | Secreted, extracellular space. [UniProt] |
| 预测分子量 | 63 kDa |
| 翻译后修饰 | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG58832 anti-LOXL1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human prostatic cancer stained with ARG58832 anti-LOXL1 antibody.
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ARG58832 anti-LOXL1 antibody WB image
Western blot: 40 µg of A549 and HeLa cell lysates stained with ARG58832 anti-LOXL1 antibody at 0.5 µg/ml dilution.
