ARG46147
anti-LMAN1 antibody
anti-LMAN1 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Mouse Monoclonal antibody recognizes LMAN1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | LMAN1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide near the carboxy terminus of human LMAN1. |
| 偶联标记 | Un-conjugated |
| 別名 | LMAN1; F5F8D; ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; FMFD1; Protein ERGIC-53; MR60; gp58; ERGIC53; Lectin mannose-binding 1; Intracellular mannose-specific lectin MR60; MCFD1; Gp58 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 纯化 | Purification with Protein A |
|---|---|
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LMAN1 |
| 全名 | lectin, mannose-binding, 1 |
| 背景介绍 | The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015] |
| 生物功能 | Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. [UniProt] |
| 细胞定位 | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 56 kDa |
| 翻译后修饰 | The N-terminal may be partly blocked. [UniProt] |
