ARG56987
anti-LITAF antibody [5C10]
anti-LITAF antibody [5C10] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [5C10] recognizes LITAF |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5C10 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | LITAF |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 1-161 of Human LITAF. |
| 偶联标记 | Un-conjugated |
| 別名 | SIMPLE; TP53I7; Small integral membrane protein of lysosome/late endosome; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; PIG7; LPS-induced TNF-alpha factor; p53-induced gene 7 protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q99732 Human Lipopolysaccharide-induced tumor necrosis factor-alpha factor |
|---|---|
| 基因名称 | LITAF |
| 全名 | lipopolysaccharide-induced TNF factor |
| 背景介绍 | Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] |
| 生物功能 | Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression. [UniProt] |
| 预测分子量 | 17 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to EGF. |
检测图片 (1) Click the Picture to Zoom In
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ARG56987 anti-LITAF antibody [5C10] WB image
Western blot: 40 µg of HeLa and HepG2 cell lysates stained with ARG56987 anti-LITAF antibody [5C10] at 1:1000 dilution.
