ARG44400
anti-LEMD3 / MAN1 antibody
anti-LEMD3 / MAN1 antibody for Flow cytometry,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LEMD3 / MAN1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LEMD3 / MAN1 |
| 抗原物种 | Human |
| 抗原 | Human LEMD3 / MAN1 recombinant protein (aa. sequence: H535-H852). |
| 偶联标记 | Un-conjugated |
| 別名 | LEMD3; LEM Domain Containing 3; MAN1; Inner Nuclear Membrane Protein Man1; LEM Domain-Containing Protein 3; MAN Antigen 1; Integral Inner Nuclear Membrane Protein; LEMD3/MKX Fusion |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y2U8 Human Inner nuclear membrane protein Man1 |
|---|---|
| 基因名称 | LEMD3 |
| 全名 | LEM Domain Containing 3 |
| 背景介绍 | This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. |
| 生物功能 | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest |
| 细胞定位 | Membrane, Nucleus |
| 预测分子量 | 100 kDa |
| 翻译后修饰 | Acetylation, Phosphoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG44400 anti-LEMD3 / MAN1 antibody WB image
Western blot: K562 stained with ARG44400 anti-LEMD3 / MAN1 antibody at 0.5 μg/mL dilution.
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ARG44400 anti-LEMD3 / MAN1 antibody FACS image
Flow Cytometry: 293T stained with ARG44400 anti-LEMD3 / MAN1 antibody at 1 μg/10^6 cells dilution.
