ARG45465
anti-LARG antibody
anti-LARG antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LARG |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LARG |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human LARG. |
| 偶联标记 | Un-conjugated |
| 別名 | ARHGEF12; Rho Guanine Nucleotide Exchange Factor 12; LARG; KIAA0382; Rho Guanine Nucleotide Exchange Factor (GEF) 12; Leukemia-Associated RhoGEF; Leukemia-Associated Rho Guanine Nucleotide Exchange Factor; KMT2A/ARHGEF12 Fusion Protein; PRO2792 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | 220 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8R4H2 Mouse Rho guanine nucleotide exchange factor 12 Swiss-port # Q9NZN5 Human Rho guanine nucleotide exchange factor 12 |
|---|---|
| 基因名称 | ARHGEF12 |
| 全名 | Rho Guanine Nucleotide Exchange Factor 12 |
| 背景介绍 | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| 生物功能 | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. [UniProt] |
| 细胞定位 | Cytoplasm; Membrane. [UniProt] |
| 预测分子量 | 173 kDa |
| 翻译后修饰 | Acetylation; Phosphoprotein. [UniProt] |
检测图片 (7) Click the Picture to Zoom In
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ARG45465 anti-LARG antibody IHC-P image
Immunohistochemistry: Human colorectal adenocarcinoma stained with ARG45465 anti-LARG antibody at 2 μg/ml dilution.
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ARG45465 anti-LARG antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45465 anti-LARG antibody at 5 μg/ml dilution.
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ARG45465 anti-LARG antibody WB image
Western blot: Hela stained with ARG45465 anti-LARG antibody at 0.5 μg/ml dilution.
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ARG45465 anti-LARG antibody FACS image
Flow Cytometry: HepG2 stained with ARG45465 anti-LARG antibody at 1 µg/10^6 cells dilution.
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ARG45465 anti-LARG antibody IHC-P image
Immunohistochemistry: Rat brain stained with ARG45465 anti-LARG antibody at 2 μg/ml dilution.
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ARG45465 anti-LARG antibody WB image
Western blot: Rat testis stained with ARG45465 anti-LARG antibody at 0.5 μg/ml dilution.
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ARG45465 anti-LARG antibody WB image
Western blot: Mouse testis stained with ARG45465 anti-LARG antibody at 0.5 μg/ml dilution.
