ARG45143
anti-LAR antibody
anti-LAR antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LAR |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LAR |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to internal region of human LAR. |
| 偶联标记 | Un-conjugated |
| 別名 | LAR; Leukocyte-antigen-related-like; |anti LAR antibody|LAR||Receptor-type tyrosine-protein phosphatase F|3.1.3.48|Leukocyte common antigen related|LAR|PTPRF|LAR|Leukocyte Antigen-Related Tyrosine Phosphatase|Protein Tyrosine Phosphatase Receptor Type F Polypeptide|Receptor-Linked Protein Tyrosine Phosphatase LAR|Leukocyte Antigen-Related LAR PTP Receptor|LCA-Homolog|BNAH2| |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 240 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P10586 Human Receptor-type tyrosine-protein phosphatase F |
|---|---|
| 基因名称 | LAR |
| 全名 | Leukocyte-antigen-related-like |
| 背景介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. [UniProt] |
| 细胞定位 | Membrane. [UniProt] |
| 预测分子量 | 213 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45143 anti-LAR antibody IHC-P image
Immunohistochemistry: Human lung cancer stained with ARG45143 anti-LAR antibody at 1 μg/ml dilution.
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ARG45143 anti-LAR antibody WB image
Western blot: Hela, A431, and A549 stained with ARG45143 anti-LAR antibody at 0.5 μg/ml dilution.
