ARG57582
anti-LAPTM4B antibody
anti-LAPTM4B antibody for Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LAPTM4B |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LAPTM4B |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 195-209 of Human LAPTM4B. |
| 偶联标记 | Un-conjugated |
| 別名 | Lysosome-associated transmembrane protein 4-beta; LAPTM4beta; LC27; Lysosomal-associated transmembrane protein 4B |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q5U1W4 Rat Lysosomal-associated transmembrane protein 4B Swiss-port # Q86VI4 Human Lysosomal-associated transmembrane protein 4B |
|---|---|
| 基因名称 | LAPTM4B |
| 全名 | lysosomal protein transmembrane 4 beta |
| 生物功能 | Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). [UniProt] |
| 细胞定位 | Endomembrane system; Multi-pass membrane protein |
| 预测分子量 | 35 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG57582 anti-LAPTM4B antibody WB image
Western blot: 20 µg of HeLa cell lysate stained with ARG57582 anti-LAPTM4B antibody at 1:1000 dilution.
