ARG54752
anti-KMT2D / MLL2 antibody
anti-KMT2D / MLL2 antibody for Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KMT2D / MLL2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KMT2D / MLL2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 4980-5009 (C-terminus) of Human MLL2 (NP_003473.3). |
| 偶联标记 | Un-conjugated |
| 別名 | KABUK1; Lysine N-methyltransferase 2D; TNRC21; AAD10; MLL2; KMS; CAGL114; MLL4; Myeloid/lymphoid or mixed-lineage leukemia protein 2; EC 2.1.1.43; Histone-lysine N-methyltransferase 2D; ALR; ALL1-related protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14686 Human Histone-lysine N-methyltransferase 2D |
|---|---|
| 基因名称 | KMT2D |
| 全名 | lysine (K)-specific methyltransferase 2D |
| 背景介绍 | The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010] |
| 生物功能 | Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. [UniProt] |
| 细胞定位 | Nucleus. |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 593 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG54752 anti-KMT2D / MLL2 antibody WB image
Western blot: 20 µg of MLL2 recombinant protein stained with ARG54752 anti-KMT2D / MLL2 antibody at 1:80000 dilution.
